Peer-reviewed Papers  (underlined names are those of undergraduates)


  1. 25.Xu W, Boyd RM; Tree MO, Samkari F; Zhao, L*, Mitochondrial transcription factor A promotes DNA strand cleavage at abasic sites, PNAS. 2019.


  1. 24.Xu W, Zhao, W; Morehouse, N; Tree MO, Zhao, L*, Divalent cations alter the rate-limiting step of PrimPol-catalyzed DNA elongation, J Mol. Biol. 2019, 431, 673-686.


  1. 23.Yockey, OP; Jha V; Ghodke PP; Xu, T; Xu, W; Ling, H; Pradeepkumar, PI; Zhao L* Mechanism of error-free DNA replication past lucidin-derived DNA damage by human DNA polymerase κ, Chem. Res. Toxicol. 2017, 30, 2023-2032.


  1. 22.Zhao, L*; Washington MT Translesion synthesis: insights into the selection and switching of DNA polymerases, Genes, 2017, 8, 24.


  1. 21.Xu, W; Kool, D; O’Flaherty, DK; Keating AM; Sacre L; Egli, M; Noronha A; Wilds, CJ; Zhao, L* O6-2’-deoxyguanosine-butylene-O6-2’-deoxyguanosine DNA interstrand cross-links are replication-blocking and mutagenic DNA lesions, Chem. Res. Toxicol. 2016, 29, 1872-1882.


  1. 20.Xu, W; Ouellette, AM; Souradyuti Ghosh, O’Neill TC; Greenberg MM; Zhao, L* Mutagenic bypass of an oxidized abasic lesion-induced DNA interstrand cross-link analogue by human translesion synthesis DNA polymerases. Biochemistry, 2015, 54, 7409-7422.


  1. 19.Xu, W; Ouellette, AM; Wawrzak, Z; Shriver, S; Anderson, SM; Zhao, L* Kinetic and structural mechanisms of (5’S)-8,5’-cyclo-2’-deoxyguanosine-induced DNA replication stalling. Biochemistry, 2015, 54, 639-651.


  1. 18.Zhao, L*; Pence, M; Eoff, R; Yuan S; Fercu, C; Guengerich, FP*. Elucidation of kinetic mechanisms of human tranlesion DNA polymerase kappa using tryptophan mutants. FEBS J, 2014, 281, 4394–4410.

 

Peer-reviewed Papers


  1. 17.Chang, SC; Fedeles, BI; Wu, J; Delaney, JC; Li, D; Zhao, L; Christov, PP; Yau, E; Singh, V; Jost, M; Drennan, C; Marnett, LJ; Rizzo, CJ; Levine, SS; Guengerich, FP; Essigmann, JM. Next-generation sequencing reveals the biological significance of the N2,3-ethenoguanine lesion in vivo. Nucl. Acids Res. 2015, 43, 5489-5500. (NAR Breakthrough Article)


  1. 16.Guengerich FP; Zhao, L; Pence, MG; Egli M, Structure and function of the translesion DNA polymerases and interactions with damaged DNA. Perspect. Sci., 2015, 4, 24-31.


  1. 15.Maddukuri, L; Shuck, SC; Eoff, RL; Zhao, L; Rizzo, CJ; Guengerich, FP; Marnett, LJ. N6-Oxopropenyl-2'-deoxyadenosine bypass by Y-family human DNA polymerases eta, kappa and iota, Biochemistry, 2013, 52, 8766–8776.


  1. 14.Pan, S; Li, D; Zhao, L; Schenkman, JB; Rusling, JF. Genotoxicity-related chemistry of human metabolites of benzo[ghi]perylene (B[ghi]P) investigated using electro-optical arrays and DNA/microsome biocolloid reactors with LC-MS/MS, Chem. Res. Toxicol. 2013, 26, 1229–1239. 


  1. 13.Patra A; Harp J; Pallan, PS; Zhao, L; Herdewijn, P; Egli, M. Structure, stability and function of 5-chlorouracil modified G:U and A:U base pairs, Nucleic Acids Res. 2013, 41, 2689-2697.


  1. 12.Zhao, L; Pence, MG; Christov, PP; Wawrzak, Z; Choi, JY; Rizzo, CJ; Egli, M; Guengerich, FP. Basis of miscoding of the DNA adduct N2,3-ethenoguanine by human Y-family DNA polymerases, J. Biol. Chem., 2012, 287, 33516-33526. (FEATURED ON THE COVER)


  1. 11.Zhao, L; Christov, PP; Kozekov, ID; Pence, MG; Pallan, PS; Rizzo, CJ; Egli, M; Guengerich, FP. Replication of N2,3-ethenoguanine by DNA polymerases, Angew. Chem. Int. Ed., 2012, 51, 5466-5469.


  1. 10.Pan, S; Zhao, L; Rusling, JF. Evaluation of electrochemiluminescent metabolic toxicity screening arrays using a multiple compound set, Anal. Chem. 2011, 83, 2754-2760.


  1. 9.Krishnan, S; Wasalathanthri, D; Zhao, L; Schenkman, JB; Rusling, JF. Efficient bioelectronic actuation of the natural catalytic pathway of human metabolic cytochrome P450s, J. Am. Chem. Soc. 2011, 133, 1459–1465.


  1. 8.Zhao, L; Schenkman JB; Rusling, JF. High throughput genotoxicity screening using magnetic bioreactors with LC-MS/MS, Anal. Chem., 2010, 82, 10172-10178.


  1. 7.Zhao, L; Schenkman JB; Rusling, J. F. Screening for reactive metabolites using electro-optical arrays featuring human liver cytosol and microsomal enzyme sources and DNA, Chem. Comm., 2009, 5386-5388. (HIGHLIGHTED AS  HOT ARTICLE)


  1. 6.Zhao, L; Krishnan, S; Zhang, Y; Schenkman, JB; Rusling, JF.  Differences in metabolite-mediated toxicity of tamoxifen in rodents versus humans elucidated with DNA/microsome electro-optical arrays and nanoreactors, Chem. Res. Toxicol. 2009, 22, 341-347.


  1. 5.Bajrami, B; Zhao, L; Schenkman, JB; Rusling, JF. Rapid LC-MS drug metabolite profiling using enzyme bioreactors in a parallel processing format, Anal. Chem., 2009, 81, 9921-9929.


  1. 4.Benbow, EM; Kelly, SP; Zhao, L.; Reutenauer, JW; Suib, SL. Oxygen reduction properties of bifunctional α-manganese oxide electrocatalysts in aqueous and organic electrolytes, J. Phys. Chem. C, 2011, 115, 22009–22017.


  1. 3.Liu, Z; Xing, Y; Chen, C; Zhao, L; Suib, SL. Framework doping of indium in manganese oxide materials: synthesis, characterization, and electrocatalytic reduction of oxygen, Chem. Mater., 2008, 20, 2069-2071.


  1. 2.Xu, L; Ding, Y; Chen, C; Zhao, L; Rimkus, C; Joesten, R; Suib, SL. 3D flowerlike alpha-nickel hydroxide with enhanced electrochemical activity synthesized by microwave-assisted hydrothermal method, Chem. Mater., 2008, 20, 308-316. 


Book Chapters


  1. 1.Zhao, L; Bajrami, B; Rusling, JF. Rapid LC-MS drug metabolite profiling using bioreactor particles, Cytochrome P450 Protocols 3rd edition, for Methods in Molecular Biology Series. Editors: Ian R. Phillips, Paul Ortiz de Montellano, Elizabeth Shephard. Humana. 2013, 129-134.

 

work Prior to CMU

Copyright 2013-2019 Zhao Lab | Contact: linlin.zhao@ucr.edu

work At CMU

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