The flow of genetic information is critically dependent on the structure and integrity of DNA. DNA is challenged by endogenous and environmental factors, which produces a plethora of DNA modifications. Certain types of DNA modification play a role in genetic regulation, whereas others can be harmful to organismal health. The overarching goal of our research is to understand the chemical and molecular mechanisms by which human genome is maintained. We are particularly interested in the interactions between DNA and proteins/enzymes in the context of DNA replication and repair in the nucleus and mitochondria. We use biochemical, biophysical, computational, and cellular approaches to gain fundamental insights into DNA maintenance with a long-term goal to inform the development of novel therapeutics or disease intervention strategies. 


our Research

Recent NEWS

We have an open postdoctoral position in proteomics. For details, please visit here.

Check out our recent publication on the novel role of TFAM (mitochondrial transcription factor A) in mitochondrial DNA degradation!

Aug 2019, the Zhao lab officially relocated to the University of California, Riverside!


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our Facility

    We are located in the state-of-the-art Multidisciplinary Research Building, UCR’s newest and largest research building. The write-up area oversees UCR Bell Tower and has a spectacular view of the snow-capped San Gabriel Mountains over the winter (picture on top of the page).